I have been exploring the formalization of a model of human senescence, mostly based on the work of John Furber, here: http://legendarypharma.com/chartbg.html. Mr. Furber has constructed a large chart based on the aging literature and current understanding. With my colleagues I worked on an environment for working with biological process models using the aging network as a pilot study (see the reference below). Since then I’ve personally taken on a Boolean network representation of part of the model, which we’ve reported at the Rocky bioinformatics conference, in the technical report and used in our ACM TIST paper, all referenced below. For more information or resources, please contact me by email.
Bryce, D., Verdicchio M.P., Kim, S. (to appear). “Planning Interventions in Biological Networks.” Transactions on Intelligent Systems and Technology
Verdicchio, M. P. and Kim, S. (2010). Reduction of Boolean Network Basins of Attraction Reveals Intervention Targets. Technical report, Arizona State University, Tempe, Arizona.
Verdicchio, M., Kim, S. (2009). “Boolean Network Models of Human Aging.” Invited oral and poster presentations at the Rocky ‘09 Bioinformatics Conference, December 10-12, Aspen, Colorado.
Bidaye, D., Dzifcak, J., Stracuzzi, D., Chimera, R., Verdicchio, M. P., Kim, S., Langley, P. “An Interactive Environment for Visualizing, Interpreting, and Revising Biological Process Models.” Poster presentation at RECOMB 2009 Conference, May 17-21, Tucson, Arizona.
Aging Symposium at ASU
Website for the December 2008 Symposium on Systems Biology of Aging
